Mostrar mensagens com a etiqueta segurança das vacinas anti-COVID. Mostrar todas as mensagens
Mostrar mensagens com a etiqueta segurança das vacinas anti-COVID. Mostrar todas as mensagens

quinta-feira, 9 de dezembro de 2021

OLHANDO O MUNDO DA MINHA JANELA, PARTE XIII

[PARTES ANTERIORES DA SÉRIE: VI ; VII ; VIII ; IX ; X ; XI ; XII ]

SOBRE A ASCENÇÃO DO TOTALITARISMO E ALGUMAS VERDADES AMARGAS DE PERMEIO 

Um golpe de Estado instaurando uma ditadura, é um acontecimento súbito. Pode ter anos de preparativos, mas o acontecimento, em si mesmo, é rápido. Pelo contrário, a instauração dum totalitarismo é um processo dilatado no tempo, é algo cumulativo, insinuante.
A mudança totalitária é tornada possível, porque as pessoas não reconhecem logo uma série de decisões e de medidas, como sendo transformações qualitativas e não pontuais, tais como o sistemático recurso à governação por decreto, a censura e outros entorses graves aos direitos humanos fundamentais, mas sempre em nome de algo aparentemente sensato, como «preservar a saúde e a segurança» das populações.
Existe uma grande massa obnubilada  (iludida) pela propaganda. Nesta massa, muitas pessoas estão num estado de tipo hipnótico, não estão nada recetivas para ouvir argumentos que contradizem a sua narrativa (psicologicamente) tranquilizadora.
Porém, estas pessoas em denegação, podem ser acordadas por algo que esteja em contradição com a narrativa do poder, mas com uma condição: É que existam uma ou várias contracorrentes, com uma voz suficientemente audível, capazes de veicular outra leitura (*) dos acontecimentos, da realidade.
Isto é válido, tanto no domínio da pandemia de COVID, como em qualquer outro âmbito coletivo da sociedade. Somente no caso de haver uma alternativa racional e um discurso explicativo do que se está a passar, um certo número irá mudar progressivamente, «virando» o seu ponto de vista. Pode-se fazer a analogia com placas tectónicas, que se deslocam no longo tempo geológico. Nunca é algo que ocorra dum momento para o outro.
Por este motivo, os poderes totalitários instauram a censura, ou seja, a proibição de falar verdade sobre certos assuntos. Em todos os regimes totalitários da História, falar-se verdade sobre assuntos inócuos foi tolerado; apenas se exercia censura em relação a assuntos sensíveis para o domínio totalitário. As narrativas, nas quais assenta a falsa legitimação das decisões e atos dos poderes totalitários, não podem jamais ser postas em causa. Quem entrar em contradição com a narrativa dominante, está sujeito à difamação, à segregação, à discriminação e à repressão a quente.
Estamos - o Mundo está - nesta malfadada descida para o autoritarismo, com tendências claras para o totalitarismo. Os verdadeiros liberais, libertários, democratas e todas/os humanistas no sentido lato, não podem deixar-se enganar: Estamos num momento histórico decisivo.
O que fizermos, ou deixarmos de fazer, vai decidir o futuro. Pois, se revelamos medo, e se nos mantemos divididos perante o poder opressor, este não hesitará em impor as mais drásticas medidas liberticidas.

Os sociopatas e psicopatas, os déspotas e seus apoiantes, sabem bem donde vem o perigo para eles. O que eles defendem, acima de tudo, são seus interesses de grupo. Se observarmos bem o seu jogo, ele consiste em manterem-se no grupo dos que possuem privilégios associados ao poder. O que os divide é exatamente a mesma coisa: Ou seja, o aliado de hoje, pode amanhã ser o rival, na luta pelo poder (ou para manter o poder).
Eles só sabem raciocinar em termos de relações de força. Não sabem o que são valores: Quando lhes perguntam os valores em que acreditam, eles respondem: «Está a perguntar-me que ações cotadas na bolsa, eu acredito irão subir?» ou algo parecido.

                                         
                                               Alice combate o monstro

Do lado positivo, finalmente vejo o despertar duma resistência cada vez mais madura, apostando na desobediência civil, na não-violência ativa, na união de todas as pessoas, por cima das clivagens políticas, ideológicas, religiosas, etc.
Tento ajudar sem demagogia, para que se construa essa consciência: ao longo dos anos, tenho insistido em fazer deste blog um espaço aberto, onde recebo e reenvio opiniões, pontos de vista, criticas neste ou aquele domínio, reflexões próprias e alheias.

Devo muito a familiares e amigos, em vários aspetos da minha vida e atividade, a quem agradeço de todo o meu coração. Porém, também devo agradecer aos que me seguem anonimamente, que são a imensa maioria, consultando estas páginas de reflexão e crítica. Graças a todos eles, esforço-me por fazer o meu melhor. São 600 a 700 visualizações/dia, em média diária. Isto significa que muitos são seguidores regulares.

Para todos um Natal em Paz e um Ano Novo de Coragem e Esperança!

--------------------
(*)
Abaixo, uma amostra de alguns cientistas e outras personalidades que responsavelmente têm colocado objeções à narrativa oficial ou «oficiosa» e têm sido «banidos» do espaço público por censores anónimos que se erigem em vigilantes da «ortodoxia»:













https://www.zerohedge.com/political/covid-19-pandemic-fear-manufactured-authorities-yale-epidemiologist


Posted by at 6 comentários:
Labels: , , , , , , , , , , , ,

quinta-feira, 18 de novembro de 2021

O JOGO DELES CHAMA-SE CONTROLO

                                                                                        Controlo policial do passaporte vacinal, na Áustria
 

As pessoas são condicionadas, como nunca foram antes, a temerem um vírus como se fosse a peste bubónica, na era medieval. 

São condicionadas a aceitar medidas cada vez mais restritivas, ao ponto de anulação dos direitos básicos das pessoas. Em simultâneo, condicionam a população a aceitar discriminação do tipo «apartheid» ou «gulag», duma parte dos seus semelhantes, apenas por estes indivíduos não aceitarem uma controvertida «vacinação».

Esta, cuja eficácia está a ser posta em causa pelos próprios dados oficiais, não é inócua, pois existe um número elevadíssimo de efeitos secundários graves, incluindo paralisias e mortes, apenas neste período de menos de 2 anos após as campanhas em massa. Ninguém pode estimar o que virá depois, daqui a uns 5 ou 6 anos, quando efeitos de longo prazo, mas não detetáveis e portanto não avaliáveis, começarem a fazer estragos. Sabe-se que Israel, país «pioneiro» na vacinação em massa da população, está experimentando um surto severo do variante Delta do SARS-Cov-2, sendo certo que este variante se instala, se reproduz e dissemina entre pessoas plenamente vacinadas (com as duas doses da Pfizer). Ora, aquilo que seria lógico, racional e científico, seria, em todos os países sujeitos a campanhas maciças de vacinação, colocar-se a questão da estratégia «todo vacinal». 

Porquê? Porque fomos avisados, há mais de um ano, por corajosos cientistas e médicos, que a vacinação maciça durante o pico epidémico tinha um efeito de seleção das estirpes ou variantes mais agressivas, ou seja, que elas conseguiam evadir as defesas imunitárias dos vacinados. Este efeito de seleção é compreendido e estudado há muitos anos. É análogo ao efeito de um antibiótico numa população bacteriana: vai selecionar os mutantes que sejam insensíveis ao antibiótico. No espaço de algumas gerações bacterianas, a população torna-se toda ela resistente. 

Isto acontece de maneira semelhante em relação a populações virais e  os anticorpos obtidos por uma vacina. Especialmente, quando essa vacina consiste em ARN mensageiro para produzir «in loco» a proteína «spike», ela própria uma proteína causadora de problemas. 

Muitas das complicações observadas em pessoas com o COVID, incluem micro- coágulos, que se vão alojar em tecidos e órgãos vitais, como o coração ou o cérebro. Por sua vez a formação desses coágulos, em particular em vasos sanguíneos, provoca a resposta do organismo conhecida por «Antibody Defense Enhancement»,  ou seja, os anticorpos do organismo vão atacar as próprias células e tecidos exibindo à superfície a tal proteína spike, causando hemorragias, coágulos, etc.

Sendo as coisas claramente assim, aquilo que dizem ser uma atitude anticientífica, nos que recusam a vacinação, não o é: Trata-se duma muito racional avaliação dos riscos inerentes, que não são justificados por uma infeção que pode ser prevenida, numa certa medida, que pode ser tratada por protocolos seguros, bem estabelecidos e comprovados (existem vários tratamentos: à base de ivermectina - que a Merck e Pfizer agora querem comercializar - mas também usando hidroxicloroquina, ou ainda os anticorpos monoclonais).

O mais grave disto tudo, é que uma parte significativa da população, incluindo médicos, não está consciente da monstruosa manipulação dos dados, não percebe que as pessoas difamadas são - muitas delas - pessoas com um profundo conhecimento de epidemiologia, de virologia, de medicina.

Aquilo que está a passar-se tem a ver com a tentativa desesperada dos poderes políticos de ocultarem o enorme fiasco da sua abordagem da epidemia de COVID, por um lado. Mas, por outro, estão cientemente a instalar os instrumentos, as condições, o aparato administrativo e repressivo, assim como a governação por decreto  (por oposição a leis discutidas e votadas nos parlamentos). 

Com efeito, eles sabem todos que está a abater-se a maior crise das nossas vidas, não somente crise financeira, como crise económica e com profundas repercussões nas sociedades. Vai haver fome, desespero; logo, as forças de repressão dos Estados vão exercer-se sobre as pessoas que se revoltam, as pessoas conscientes do que está a ocorrer e que não se acobardam. A inflação vai destruir a vida de muitas pessoas. O que vai acontecer é, não apenas o empobrecimento devido à enorme carestia, mas também o efeito dominó da destruição de muitos postos de trabalho, aumentando brutalmente a taxa de desemprego. Os Estados e seus agentes estão a preparar-se para isso. Faz parte da sua estratégia, ocultar, desviar a atenção das pessoas. Tudo o que seja dividir para reinar vai ser usado, como já tem sido. As medidas repressivas irão continuar e com maior força, à medida que a crise se for agravando. 

Dada a disparidade de forças em presença, não acredito num desfecho favorável para o povo: Receio que ocorra um longo período de recuos em termos sociais, de liberdades e civilização, em especial, nos países que se orgulhavam de viver em democracia. Os direitos nominais, consagrados nas constituições e nas principais leis vão continuar no papel, mas serão letra morta, devido ao instaurado estado de exceção permanente.

NOTA1: Veja o caso da Irlanda, vacinada a 93 %

NOTA 2: Veja a Alemanha a copiar as medidas da Áustria

NOTA 3: Nos vacinados 9 vezes mais provável hospitalização por COVID

Posted by at 8 comentários:
Labels: , , , , , , , , ,

sexta-feira, 4 de junho de 2021

APELO DE 57 CIENTISTAS E MÉDICOS: QUESTÕES URGENTES ÀS AUTORIDADES SANITÁRIAS E GOVERNOS

  A MAIOR PARTE DAS PESSOAS LIMITA-SE A SEGUIR AS ORDENS DOS SEUS GOVERNOS. Mas estes cientistas e médicos de renome não fizeram isso; antes levantam uma série de questões que têm sido sonegadas ao grande público e que obrigam os órgãos de poder e de gestão da saúde a tomar uma posição. 

Já não poderão - nem eles nem ninguém, daqui por diante - dizer «não sabíamos.»

É favor divulgar amplamente este apelo/carta aberta.

...............................

Original Source: Authorea

SARS-CoV-2 mass vaccination: Urgent questions on vaccine safety that demand answers from international health agencies, regulatory authorities, governments and vaccine developers

Abstract

Since the start of the COVID-19 outbreak, the race for testing new platforms designed to confer immunity against SARS-CoV-2, has been rampant and unprecedented, leading to emergency authorization of various vaccines. Despite progress on early multidrug therapy for COVID-19 patients, the current mandate is to immunize the world population as quickly as possible. The lack of thorough testing in animals prior to clinical trials, and authorization based on safety data generated during trials that lasted less than 3.5 months, raise questions regarding the safety of these vaccines. The recently identified role of SARS-CoV-2 glycoprotein Spike for inducing endothelial damage characteristic of COVID-19, even in absence of infection, is extremely relevant given that most of the authorized vaccines induce the production of Spike glycoprotein in the recipients. Given the high rate of occurrence of adverse effects, and the wide range of types of adverse effects that have been reported to date, as well as the potential for vaccine-driven disease enhancement, Th2-immunopathology, autoimmunity, and immune evasion, there is a need for a better understanding of the benefits and risks of mass vaccination, particularly in the groups that were excluded in the clinical trials. Despite calls for caution, the risks of SARS-CoV-2 vaccination have been minimized or ignored by health organizations and government authorities. We appeal to the need for a pluralistic dialogue in the context of health policies, emphasizing critical questions that require urgent answers if we wish to avoid a global erosion of public confidence in science and public health.

Introduction

Since COVID-19 was declared a pandemic in March 2020, over 150 million cases and 3 million deaths have been reported worldwide. Despite progress on early ambulatory, multidrug-therapy for high-risk patients, resulting in 85% reductions in COVID-19 hospitalization and death [1], the current paradigm for control is mass-vaccination. While we recognize the effort involved in development, production and emergency authorization of SARS-CoV-2 vaccines, we are concerned that risks have been minimized or ignored by health organizations and government authorities, despite calls for caution [2-8].

Vaccines for other coronaviruses have never been approved for humans, and data generated in the development of coronavirus vaccines designed to elicit neutralizing antibodies show that they may worsen COVID-19 disease via antibody-dependent enhancement (ADE) and Th2 immunopathology, regardless of the vaccine platform and delivery method [9-11]. Vaccine-driven disease enhancement in animals vaccinated against SARS-CoV and MERS-CoV is known to occur following viral challenge, and has been attributed to immune complexes and Fc-mediated viral capture by macrophages, which augment T-cell activation and inflammation [11-13].

In March 2020, vaccine immunologists and coronavirus experts assessed SARS-CoV-2 vaccine risks based on SARS-CoV-vaccine trials in animal models. The expert group concluded that ADE and immunopathology were a real concern, but stated that their risk was insufficient to delay clinical trials, although continued monitoring would be necessary [14]. While there is no clear evidence of the occurrence of ADE and vaccine-related immunopathology in volunteers immunized with SARS-CoV-2 vaccines [15], safety trials to date have not specifically addressed these serious adverse effects (SAE). Given that the follow-up of volunteers did not exceed 2-3.5 months after the second dose [16-19], it is unlikely such SAE would have been observed. Despite92 errors in reporting, it cannot be ignored that even accounting for the number of vaccines administered, according to the US Vaccine Adverse Effect Reporting System (VAERS), the number of deaths per million vaccine doses administered has increased more than 10-fold. We believe there is an urgent need for open scientific dialogue on vaccine safety in the context of large-scale immunization. In this paper, we describe some of the risks of mass vaccination in the context of phase 3 trial exclusion criteria and discuss the SAE reported in national and regional adverse effect registration systems. We highlight unanswered questions and draw attention to the need for a more cautious approach to mass vaccination.

SARS-CoV-2 phase 3 trial exclusion criteria

With few exceptions, SARS-CoV-2 vaccine trials excluded the elderly [16-19], making it impossible to identify the occurrence of post-vaccination eosinophilia and enhanced inflammation in elderly people. Studies of SARS-CoV vaccines showed that immunized elderly mice were at particularly high risk of life-threatening Th2 immunopathology [9,20]. Despite this evidence and the extremely limited data on safety and efficacy of SARS-CoV-2 vaccines in the elderly, mass-vaccination campaigns have focused on this age group from the start. Most trials also excluded pregnant and lactating volunteers, as well as those with chronic and serious conditions such as tuberculosis, hepatitis C, autoimmunity, coagulopathies, cancer, and immune suppression [16-29], although these recipients are now being offered the vaccine under the premise of safety.

Another criterion for exclusion from nearly all trials was prior exposure to SARS-CoV-2. This is unfortunate as it denied the opportunity of obtaining extremely relevant information concerning post-vaccination ADE in people that already have anti-SARS-Cov-2 antibodies. To the best of our knowledge, ADE is not being monitored systematically for any age or medical condition group currently being administered the vaccine. Moreover, despite a substantial proportion of the population already having antibodies [21], tests to determine SARS-CoV-2-antibody status prior to administration of the vaccine are not conducted routinely.

Will serious adverse effects from the SARS-CoV-2 vaccines go unnoticed?

COVID-19 encompasses a wide clinical spectrum, ranging from very mild to severe pulmonary pathology and fatal multi-organ disease with inflammatory, cardiovascular, and blood coagulation dysregulation [22-24]. In this sense, cases of vaccine-related ADE or immunopathology would be clinically-indistinguishable from severe COVID-19 [25]. Furthermore, even in the absence of SARS-CoV-2 virus, Spike glycoprotein alone causes endothelial damage and hypertension in vitro and in vivo in Syrian hamsters by down-regulating angiotensin-converting enzyme 2 (ACE2) and impairing mitochondrial function [26]. Although these findings need to be confirmed in humans, the implications of this finding are staggering, as all vaccines authorized for emergency use are based on the delivery or induction of Spike glycoprotein synthesis. In the case of mRNA vaccines and adenovirus-vectorized vaccines, not a single study has examined the duration of Spike production in humans following vaccination. Under the cautionary principle, it is parsimonious to consider vaccine-induced Spike synthesis could cause clinical signs of severe COVID-19, and erroneously be counted as new cases of SARS-CoV-2 infections. If so, the true adverse effects of the current global vaccination strategy may never be recognized unless studies specifically examine this question. There is already non-causal evidence of temporary or sustained increases138 in COVID-19 deaths following vaccination in some countries (Fig. 1) and in light of Spike’s pathogenicity, these deaths must be studied in depth to determine whether they are related to vaccination.

Unanticipated adverse reactions to SARS-CoV-2 vaccines

Another critical issue to consider given the global scale of SARS-CoV-2 vaccination is autoimmunity. SARS-CoV-2 has numerous immunogenic proteins, and all but one of its immunogenic epitopes have similarities to human proteins [27]. These may act as a source of antigens, leading to autoimmunity [28]. While it is true that the same effects could be observed during natural infection with SARS-CoV-2, vaccination is intended for most of the world population, while it is estimated that only 10% of the world population has been infected by SARS-CoV-2, according to Dr. Michael Ryan, head of emergencies at the World Health Organization. We have been unable to find evidence that any of the currently authorized vaccines screened and excluded homologous immunogenic epitopes to avoid potential autoimmunity due to pathogenic priming.

Some adverse reactions, including blood-clotting disorders, have already been reported in healthy and young vaccinated people. These cases led to the suspension or cancellation of the use of adenoviral vectorized ChAdOx1-nCov-19 and Janssen vaccinesin some countries. It has now been proposed that vaccination with ChAdOx1-nCov-19 can result in immune thrombotic thrombocytopenia (VITT) mediated by platelet-activating antibodies against Platelet factor-4, which clinically mimics autoimmune heparin-induced thrombocytopenia [29]. Unfortunately, the risk was overlooked when authorizing these vaccines, although adenovirus-induced thrombocytopenia has been known for more than a decade, and has been a consistent event with adenoviral vectors [30]. The risk of VITT would presumably be higher in those already at risk of blood clots, including women who use oral contraceptives [31], making it imperative for clinicians to advise their patients accordingly.

At the population level, there could also be vaccine-related impacts. SARS-CoV-2 is a fast-evolving RNA virus that has so far produced more than 40,000 variants [32,33] some of which affect the antigenic domain of Spike glycoprotein [34,35]. Given the high mutation rates, vaccine-induced synthesis of high levels of anti-SARS-CoV-2-Spike antibodies could theoretically lead to suboptimal responses against subsequent infections by other variants in vaccinated individuals [36], a phenomenon known as “original antigenic sin” [37] or antigenic priming [38]. It is unknown to what extent mutations that affect SARS-CoV-2 antigenicity will become fixed during viral evolution [39], but vaccines could plausibly act as selective forces driving variants with higher infectivity or transmissibility. Considering the high similarity between known SARS-CoV-2 variants, this scenario is unlikely [32,34] but if future variants were to differ more in key epitopes, the global vaccination strategy might have helped shape an even more dangerous virus. This risk has recently been brought to the attention of the WHO as an open letter [40].

Discussion

The risks outlined here are a major obstacle to continuing global SARS-CoV-2 vaccination. Evidence on the safety of all SARS-CoV-2 vaccines is needed before exposing more people to the184 risk of these experiments, since releasing a candidate vaccine without time to fully understand the resulting impact on health could lead to an exacerbation of the current global crisis [41]. Risk-stratification of vaccine recipients is essential. According to the UK government, people below 60 years of age have an extremely low risk of dying from COVID-191 187 . However, according to Eudravigillance, most of the serious adverse effects following SARS-CoV-2 vaccination occur in people aged 18-64. Of particular concern is the planned vaccination schedule for children aged 6 years and older in the United States and the UK. Dr. Anthony Fauci recently anticipated that teenagers across the country will be vaccinated in the autumn and younger children in early 2022, and the UK is awaiting trial results to commence vaccination of 11 million children under 18. There is a lack of scientific justification for subjecting healthy children to experimental vaccines, given that the Centers for Disease Control and Prevention estimates that they have a 99.997% survival rate if infected with SARS-CoV-2. Not only is COVID-19 irrelevant as a threat to this age group, but there is no reliable evidence to support vaccine efficacy or effectiveness in this population or to rule out harmful side effects of these experimental vaccines. In this sense, when physicians advise patients on the elective administration of COVID-19 vaccination, there is a great need to better understand the benefits and risk of administration, particularly in understudied groups.

In conclusion, in the context of the rushed emergency-use-authorization of SARS-CoV-2 vaccines, and the current gaps in our understanding of their safety, the following questions must be raised:

  • Is it known whether cross-reactive antibodies from previous coronavirus infections or vaccine206 induced antibodies may influence the risk of unintended pathogenesis following vaccination with COVID-19?
  • Has the specific risk of ADE, immunopathology, autoimmunity, and serious adverse reactions been clearly disclosed to vaccine recipients to meet the medical ethics standard of patient understanding for informed consent? If not, what are the reasons, and how could it be implemented?
  • What is the rationale for administering the vaccine to every individual when the risk of dying from COVID-19 is not equal across age groups and clinical conditions and when the phase 3 trials excluded the elderly, children and frequent specific conditions?
  • What are the legal rights of patients if they are harmed by a SARS-CoV-2 vaccine? Who will cover the costs of medical treatment? If claims were to be settled with public money, has the public been made aware that the vaccine manufacturers have been granted immunity, and their responsibility to compensate those harmed by the vaccine has been transferred to the tax-payers?

In the context of these concerns, we propose halting mass-vaccination and opening an urgent pluralistic, critical, and scientifically-based dialogue on SARS-CoV-2 vaccination among scientists, medical doctors, international health agencies, regulatory authorities, governments, and vaccine developers. This is the only way to bridge the current gap between scientific evidence and public health policy regarding the SARS-CoV-2 vaccines. We are convinced that humanity deserves a deeper understanding of the risks than what is currently touted as the official position. An open scientific dialogue is urgent and indispensable to avoid erosion of public confidence in science and public health and to ensure that the WHO and national health authorities protect the interests of humanity during the current pandemic. Returning public health policy to evidence-based medicine, relying on a careful evaluation of the relevant scientific research, is urgent. It is imperative to follow the science.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

*

Note to readers: Please click the share buttons above or below. Follow us on Instagram, @crg_globalresearch. Forward this article to your email lists. Crosspost on your blog site, internet forums. etc.

Notes on Authors

1Epidemiólogos Argentinos Metadisciplinarios. República Argentina.

2Baylor University Medical Center. Dallas, Texas, USA.

3Monestir de Sant Benet de Montserrat, Montserrat, Spain

4INSERM U781 Hôpital Necker-Enfants Malades, Université Paris Descartes-Sorbonne Cité, Institut Imagine, Paris, France.

5School of Natural Sciences. Autonomous University of Querétaro, Querétaro, Mexico.

6Retired Professor of Medical Immunology. Universidad de Guadalajara, Jalisco, Mexico.

7Médicos por la Verdad Puerto Rico. Ashford Medical Center. San Juan, Puerto Rico.

8Retired Professor of Clinical Diagnostic Processes. University of Murcia, Murcia, Spain

9Urologist Hospital Comarcal de Monforte, University of Santiago de Compostela, Spain.

10Biólogos por la Verdad, Spain.

11Retired Biologist. University of Barcelona. Specialized in Microbiology. Barcelona, Spain.

12Center for Integrative Medicine MICAEL (Medicina Integrativa Centro Antroposófico Educando en Libertad). Mendoza, República Argentina.

13Médicos por la Verdad Argentina. República Argentina. ´

14Médicos por la Verdad Uruguay. República Oriental del Uruguay.

15Médicos por la Libertad Chile. República de Chile.

16Physician, orthopedic specialist. República de Chile.

17Médicos por la Verdad Perú. República del Perú.

18Médicos por la Verdad Guatemala. República de Guatemala.

19Concepto Azul S.A. Ecuador.

20Médicos por la Verdad Brasil. Brasil.

21Médicos por la Verdad Paraguay.

22Médicos por la Costa Rica.

23Médicos por la Verdad Bolivia.

24Médicos por la Verdad El Salvador.

25Correspondence: Karina Acevedo-Whitehouse, karina.acevedo.whitehouse@uaq.mx

Sources

https://www.gov.uk/government/publications/covid-19-reported-sars-cov-2-deaths-in-england/covid-19-confirmed-deaths-in-england-report

Notes

  1. McCullough PA, Alexander PE, Armstrong R, et al. Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Rev Cardiovasc Med (2020) 21:517–530. doi:10.31083/j.rcm.2020.04.264
  2. Arvin AM, Fink K, Schmid MA, et al. A perspective on potential antibody- dependent enhancement of SARS-CoV-2. Nature (2020) 484:353–363. doi:10.1038/s41586-020-2538-8
  3. Coish JM, MacNeil AJ. Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19. Microbes Infect (2020) 22(9):405-406. doi:10.1016/j.micinf.2020.06.006
  4. Eroshenko N, Gill T, Keaveney ML, et al. Implications of antibody-dependent enhancement of infection for SARS-CoV-2 countermeasures. Nature Biotechnol (2020) 38:788–797. doi:10.1038/s41587-020-0577-1
  5. Poland GA. Tortoises, hares, and vaccines: A cautionary note for SARS-CoV-2 vaccine development. Vaccine (2020) 38:4219–4220. doi:10.1016/j.vaccine.2020.04.073
  6. Shibo J. Don’t rush to deploy COVID-19 vaccines and drugs without sufficient safety guarantees. Nature (2000) 579,321. doi:10.1038/d41586-020-00751-9
  7. Munoz FA, Cramer JP, Dekker CL, et al. Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine (2021) https://doi.org/10.1016/j.vaccine.2021.01.055
  8. Cardozo T, Veazey R. Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease. Int J Clin Pract (2020) 28:e13795. doi: 10.1111/ijcp.13795
  9. Bolles D, Long K, Adnihothram S, et al. A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge. J Virol (2001) 85:12201–12215. doi:10.1128/JVI.06048-11
  10. Weingartl H, Czub M, Czub S, et al. Immunization with modified vaccinia virus Ankarabased recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets. J Virol (2004) 78:12672–12676. doi:10.1128/JVI.78.22.12672-12676.2004272
  11. Tseng CT, Sbrana E, Iwata-Yoshikawa N, et al. Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. PLoS One (2012) 7(4):e35421. doi: 10.1371/journal.pone.0035421
  12. Iwasaki A, Yang Y. The potential danger of suboptimal antibody responses in COVID-19. Nat Rev Immunol (2020) 20:339–341. doi:10.1038/s41577-020-0321-6
  13. Vennema H, de Groot RJ, Harbour DA, et al. Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization. J Virol (1990) 64:1407-1409
  14. Lambert PH, Ambrosino DM, Andersen SR, et al. Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines. Vaccine (2020) 38(31):4783-4791. doi:10.1016/j.vaccine.2020.05.064
  15. de Alwis R, Chen S, Gan S, et al. Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EbioMedicine (2020) 55:102768. doi:10.1016/j.ebiom.2020.102768
  16. Folegatti PM, Ewer KJ, Aley PK, et al. Safety and immunogenicity of the ChAdOx1 nCoV287 19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet (2020) 396:467–783. doi:10.1016/S0140-6736(20)31604-4
  17. Polack FP, Thomas SJ, Kitchin N. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med (2020) 383:2603–2615. doi:10.1056/NEJMoa2034577
  18. Ramasamy MN, Minassian AM, Ewer KJ, et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. Lancet (2021) 396:1979–93. doi: 10.1016/S0140-6736(20)32466-1
  19. Chu L, McPhee R, Huang W, et al. mRNA-1273 Study Group. A preliminary report of a randomized controlled phase 2 trial of the safety and immunogenicity of mRNA-1273 SARS-CoV-2 vaccine. Vaccine (2021) S0264-410X(21)00153-5. doi:10.1016/j.vaccine.2021.02.007
  20. Liu L, Wei Q, Lin Q, et al. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight (2019) 4(4):e123158. doi:10.1172/jci.insight.123158.
  21. Ioannidis PA. Infection fatality rate of COVID-19 inferred from seroprevalence data. Bull WHO (2021) 99:19–33F. http://dx.doi.org/10.2471/BLT.20.265892
  22. Martines RB, Ritter JM, Matkovic E, et al. Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States Emerg Infect Dis (2020) 26:2005-2015. doi:10.3201/eid2609.202095
  23. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA (2020) 323:1239-1242. doi:10.1001/jama.2020.2648
  24. Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respiratory Med (2020) 8:420-422 doi:10.1016/S2213-2600(20)30076-X
  25. Negro F. Is antibody-dependent enhancement playing a role in COVID-19 pathogenesis? Swiss Medical Weekly (2020) 150:w20249. doi:10.4414/smw.2020.20249317
  26. Lei Y, Zhang J, Schiavon CR et al., Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Res (2021) 128:1323–1326. https://doi.org/10.1161/CIRCRESAHA.121.318902
  27. Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity, J Translational Autoimmunity (2020) 3:100051. doi:10.1016/j.jtauto.2020.100051
  28. An H, Park J. Molecular Mimicry Map (3M) of SARS-CoV-2: Prediction of potentially immunopathogenic SARS-CoV-2 epitopes via a novel immunoinformatic approach. bioRxiv [Preprint]. 12 November 2020 [cited 2020 April 19] https://doi.org/10.1101/2020.11.12.344424
  29. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. N Engl J Med (2021). doi: 10.1056/NEJMoa2104840
  30. Othman M, Labelle A, Mazzetti I et al. Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance. Blood (2007) 109:2832–2839. doi:10.1182/blood-2006-06-032524
  31. Ortel TL. Acquired thrombotic risk factors in the critical care setting. Crit Care Med (2010) 38(2 Suppl):S43-50. doi:10.1097/CCM.0b013e3181c9ccc8
  32. Grubaugh ND, Petrone ME, Holmes EC. We shouldn’t worry when a virus mutates during disease outbreaks. Nat Microbiol (2020) 5:529–530. https://doi.org/10.1038/s41564-020-0690-4
  33. Greaney AJ, Starr TN, Gilchuk P, et al. Complete Mapping of Mutations to the SARS-CoV339 2 Spike Receptor-Binding Domain that Escape Antibody Recognition. Cell Host Microbe (2021) 29:44–57.e9. doi:10.1016/j.chom.2020.11.007.
  34. Lauring AS, Hodcroft EB. Genetic Variants of SARS-CoV-2—What Do They Mean? JAMA (2021) 325:529–531. doi:10.1001/jama.2020.27124
  35. Zhang L, Jackson CB, Mou H, et al. The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. bioRxiv [Preprint]. June 12 2020 [cited 2021 Apr 19] https://doi.org/10.1101/2020.06.12.148726
  36. Korber B, Fischer WM, Gnanakaran S et al. Sheffield COVID-19 Genomics Group. Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell (2020) 182:812-827.e19. doi:10.1016/j.cell.2020.06.043
  37. Francis T. On the doctrine of original antigenic sin. Proc Am Philos Soc (1960) 104:572–578.
  38. Vibroud C, Epstein SL. First flu is forever. Science (2016) 354:706–707. doi:10.1126/science.aak9816
  39. Weisblum Y, Schmidt F, Zhang F, et al. Escape from neutralizing antibodies by SARS354 CoV-2 spike protein variants. Elife (2020) 9:e61312. doi:10.7554/eLife.61312
  40. Vanden Bossche G (March 6, 2021) https://dryburgh.com/wp-356content/uploads/2021/03/Geert_Vanden_Bossche_Open_Letter_WHO_March_6_2021.pdf
  41. Coish JM, MacNeil AJ. Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19. Microbes Infect (2020) 22(9):405-406. doi:10.1016/j.micinf.2020.06.006
Posted by at 5 comentários:
Labels: ,
Subscrever: Mensagens (Atom)